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Related Experiment Videos

[Pseudomembranous rectocolitis].

J Débat, A G Prévost, V Coliche

    Annales De Gastroenterologie Et D'Hepatologie
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Pseudo-membranous coloproctitis (PMCP) affects all ages and sexes, often linked to antibiotics. Diagnosis relies on endoscopy and histology, with Clostridium difficile identified as the pathogen.

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    [Anorectal lesions in hemopathies].

    Annales de gastroenterologie et d'hepatologie·1986

    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Colorectal Surgery

    Background:

    • Pseudo-membranous coloproctitis (PMCP) is a severe intestinal condition.
    • Antibiotic use is a significant risk factor for PMCP development.

    Purpose of the Study:

    • To investigate the clinical presentation, diagnosis, and treatment of PMCP.
    • To identify the causative agent and pathological features of PMCP.

    Main Methods:

    • Retrospective analysis of 15 PMCP cases.
    • Clinical evaluation, endoscopy, histological examination, and imaging studies (abdominal X-ray, barium enema).
    • Microbiological investigation focusing on Clostridium difficile detection.

    Main Results:

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  • PMCP occurred across all ages and sexes, associated with various antibiotic classes.
  • Common symptoms included diarrhea, fever, and abdominal pain; surgical findings indicated pseudo-obstruction or perforation.
  • Endoscopy revealed pseudo-membranes, predominantly in the left colon, with severity increasing distally.
  • Histology identified three stages: superficial necrosis, gland interruption, and complete mucosal necrosis.
  • Abdominal X-rays and barium enemas lacked specificity, while conventional coprocultures were uninformative for Clostridium difficile.

    • Conclusions:

    • PMCP diagnosis is confirmed by endoscopic visualization of pseudo-membranes and histological staging.
    • Clostridium difficile is the primary pathogen, detectable by specialized techniques.
    • While medical management (parenteral nutrition, vancomycin) is often effective, surgical intervention may be necessary in some cases.