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Dietary intervention reprograms bone marrow cellular signaling in obese mice
Yuxuan Zheng1, Jiren Yan2, Xiaofu Zhang3
1Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China.
Frontiers in Endocrinology
|August 2, 2023
Summary
High-fat diets impair bone formation, but dietary intervention can reverse this effect by modulating osteogenesis and adipogenesis. Targeting the Wingless-related integration site (Wnt) signaling pathway shows promise for treating obesity-related bone loss.
Area of Science:
- Metabolic bone disease
- Obesity pathogenesis
- Nutritional science
Background:
- Obesity is linked to impaired bone mass accrual.
- Understanding the mechanisms behind obesity-induced bone density changes is crucial.
Purpose of the Study:
- Investigate how obesity affects bone mass accrual.
- Evaluate the impact of dietary intervention on bone density in obese mice.
Main Methods:
- Mice were fed a chow diet (CD), high-fat diet (HFD), or HFD followed by a chow diet (HFDt).
- Bone density, osteogenesis, adipogenesis, and Wingless-related integration site (Wnt)-β-Catenin signaling were assessed.
Main Results:
- HFD feeding led to bone mass accrual and decreased Wnt signaling.
- Dietary intervention in HFDt mice resulted in weight loss, reduced intrahepatic lipids, and improved bone density.
- HFDt mice showed increased osteogenesis and decreased adipogenesis compared to HFD mice.
Conclusions:
- High-fat diets inhibit bone formation, while dietary intervention reverses this effect.
- Dietary intervention can restore bone mass to levels comparable to controls.
- Targeting the Wnt signaling pathway may offer a therapeutic strategy for obesity-induced bone loss.
