Related Experiment Video

Updated: Jul 20, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.0K

Indication-driven order entry decreases stewardship and pharmacist interventions

Jacey L Nishiguchi1, Laura L Bio1, Sean T Cornell2

  • 1Department of Pharmacy, Lucile Packard Children's Hospital Stanford, Palo Alto, California.

Infection Control and Hospital Epidemiology
|August 2, 2023
PubMed

Insights

Indication-driven order entry (IDOE) reduced antimicrobial stewardship program interventions. This system streamlines antibiotic ordering, decreasing recommendations and pharmacist actions for key drugs.

Area of Science:

  • Pediatric infectious diseases
  • Antimicrobial stewardship
  • Health informatics

Background:

  • Prospective audit and feedback (PAF) is a key antimicrobial stewardship program (ASP) strategy.
  • Cefazolin, piperacillin-tazobactam, and meropenem are frequently targeted for intervention due to high usage.
  • Inefficient order entry systems can contribute to suboptimal antibiotic prescribing.

Purpose of the Study:

  • To evaluate the impact of implementing indication-driven order entry (IDOE) on antibiotic prescribing.
  • To assess changes in antimicrobial stewardship program (ASP) interventions after IDOE implementation.
  • To determine the effect of IDOE on clinical pharmacist interventions.

Main Methods:

  • Implementation of indication-driven order entry (IDOE) for specific antibiotics.
  • Prospective audit and feedback (PAF) by the antimicrobial stewardship program (ASP) before and after IDOE.
  • Tracking of ASP recommendations and clinical pharmacist interventions.

Main Results:

  • IDOE implementation was associated with a significant reduction in ASP PAF recommendations.
  • A notable decrease in clinical pharmacist interventions was observed post-IDOE.
  • The system effectively streamlined the ordering process for targeted antibiotics.

Conclusions:

  • Indication-driven order entry (IDOE) is an effective strategy for reducing antimicrobial stewardship program (ASP) interventions.
  • IDOE can optimize antibiotic prescribing practices in pediatric settings.
  • Integrating clinical decision support into electronic health records enhances antimicrobial stewardship.

More Related Videos

Improving IV Insulin Administration in a Community Hospital12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

18.9K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.5K

Related Concept Videos

Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K
Types of Reports III: Telephone and Verbal Reports01:26

Types of Reports III: Telephone and Verbal Reports

Telephone and Verbal Reports in healthcare settings are two communication methods for conveying therapeutic instructions from healthcare providers to nurses or other healthcare staff.
Here's an overview of each type:
Telephone Orders
774
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
540
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
69
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
891
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
765