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Related Experiment Video

Updated: Jul 20, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Indication-driven order entry decreases stewardship and pharmacist interventions.

Jacey L Nishiguchi¹, Laura L Bio¹, Sean T Cornell²

¹Department of Pharmacy, Lucile Packard Children's Hospital Stanford, Palo Alto, California.

Infection Control and Hospital Epidemiology

|August 2, 2023

Summary

Indication-driven order entry (IDOE) reduced antimicrobial stewardship program interventions. This system streamlines antibiotic ordering, decreasing recommendations and pharmacist actions for key drugs.

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A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

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Published on: November 9, 2016

Area of Science:

Pediatric infectious diseases
Antimicrobial stewardship
Health informatics

Background:

Prospective audit and feedback (PAF) is a key antimicrobial stewardship program (ASP) strategy.
Cefazolin, piperacillin-tazobactam, and meropenem are frequently targeted for intervention due to high usage.
Inefficient order entry systems can contribute to suboptimal antibiotic prescribing.

Purpose of the Study:

To evaluate the impact of implementing indication-driven order entry (IDOE) on antibiotic prescribing.
To assess changes in antimicrobial stewardship program (ASP) interventions after IDOE implementation.
To determine the effect of IDOE on clinical pharmacist interventions.

Main Methods:

Implementation of indication-driven order entry (IDOE) for specific antibiotics.
Prospective audit and feedback (PAF) by the antimicrobial stewardship program (ASP) before and after IDOE.
Tracking of ASP recommendations and clinical pharmacist interventions.

Main Results:

IDOE implementation was associated with a significant reduction in ASP PAF recommendations.
A notable decrease in clinical pharmacist interventions was observed post-IDOE.
The system effectively streamlined the ordering process for targeted antibiotics.

Conclusions:

Indication-driven order entry (IDOE) is an effective strategy for reducing antimicrobial stewardship program (ASP) interventions.
IDOE can optimize antibiotic prescribing practices in pediatric settings.
Integrating clinical decision support into electronic health records enhances antimicrobial stewardship.