Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Cancer Survival Analysis01:21

Cancer Survival Analysis

384
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
384
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Cancer Therapies02:49

Cancer Therapies

7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
Cancer Vaccines01:30

Cancer Vaccines

405
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
405

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expectations predict early pregnancy-related symptom burden.

Scientific reports·2026
Same author

A Digital Diabetes Self-Management Education and Support Program Integrated With Continuous Glucose Monitoring for Type 2 Diabetes: Randomized Controlled Trial.

Journal of medical Internet research·2026
Same author

Contributions of the basolateral amygdala and nucleus accumbens to sustaining not just initiating cognitive effort.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Psychosocial interventions indicate prolonged survival in cancer patients in a systematic review, meta-analysis, and multiverse meta-analysis of randomized controlled trials.

Communications psychology·2026
Same author

Social media impact and smartwatch monitoring: Prevalence and early markers of PTSD and anxiety following mass traumatic events.

PLOS mental health·2026
Same author

Accelerated recovery using magnesium ibogaine: characterizing the subjective experience of its rapid healing from neuropsychiatric disorders.

Npj mental health research·2026

Related Experiment Video

Updated: Jul 20, 2025

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.7K

Changing cancer mindsets: A randomized controlled feasibility and efficacy trial.

Sean R Zion1, Lidia Schapira2, Jonathan S Berek2,3

  • 1Department of Psychology, Stanford University, Stanford, California, USA.

Psycho-Oncology
|August 2, 2023
PubMed
Summary

A new digital intervention improved cancer patients' quality of life by targeting their mindsets about illness. This Cancer Mindset Intervention (CMI) enhanced coping and reduced symptom distress, offering a novel approach to supportive cancer care.

Keywords:
cancerdigital interventionhealth related quality of life (HRQoL)mindsetsoncologypsychologically wise interventionsupportive care

More Related Videos

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

8.4K
Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
10:10

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

12.7K

Related Experiment Videos

Last Updated: Jul 20, 2025

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.7K
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

8.4K
Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
10:10

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

12.7K

Area of Science:

  • Oncology
  • Digital Health
  • Psychological Interventions

Background:

  • Cancer diagnosis and treatment significantly impact patients' physical, social, emotional, and functional quality of life.
  • Existing psychological treatments often focus on specific symptoms rather than the overall patient experience.
  • There is a need for interventions that address patients' core assumptions about illness to improve their well-being.

Purpose of the Study:

  • To evaluate the feasibility and efficacy of a novel digital intervention, the Cancer Mindset Intervention (CMI).
  • To assess the CMI's impact on overall health-related quality of life (HRQoL) in newly diagnosed cancer patients.
  • To examine the intervention's effects on coping behaviors and symptom distress.

Main Methods:

  • A decentralized clinical trial involving 361 adult patients with newly diagnosed non-metastatic cancers undergoing systemic treatment.
  • Randomization of participants to either the Cancer Mindset Intervention (CMI) group or Treatment as Usual (TAU) group.
  • The CMI group completed seven online modules over 10 weeks focused on cancer and body-related mindsets; primary outcome was HRQoL.

Main Results:

  • Patients in the CMI group showed significant improvements in adaptive mindsets regarding cancer and the body.
  • The CMI group reported significant improvements in overall HRQoL compared to the TAU group (p < 0.001).
  • CMI led to increased adaptive coping behaviors (p < 0.001) and reduced physical symptom distress (p < 0.01) with moderate effect sizes (d = 0.42–0.54).

Conclusions:

  • A brief, mindset-focused digital intervention effectively improved multiple aspects of HRQoL in newly diagnosed cancer patients.
  • The Cancer Mindset Intervention demonstrated efficacy in enhancing adaptive coping and reducing symptom distress.
  • This digital approach offers a promising strategy for improving the holistic patient experience during cancer treatment.