Related Experiment Video
Updated: Jul 20, 2025

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Recurrent miscarriage and infertility: a national service evaluation
Laura Linehan1,2, Marita Hennessy1,2, Keelin O'Donoghue1,2
1Department of Obstetrics and Gynaecology, Pregnancy Loss Research Group, University College Cork, Cork, Ireland.
Clinical care for recurrent miscarriage (RM) and infertility often lacks standardization. This study found variations in treatments and limited outcome audits, highlighting a need for improved, integrated fertility services and mandatory outcome reporting for better patient care.
Area of Science:
- Reproductive Medicine and Infertility
- Maternal-Fetal Medicine
- Clinical Quality Improvement
Background:
- International guidelines inadequately address the clinical care of women/couples with infertility and recurrent miscarriage (RM).
- Existing RM care is known to be variable and often deviates from recommended guidance.
Purpose of the Study:
- To evaluate the provision of clinical care for women/couples experiencing infertility and recurrent miscarriage (RM) across public and private healthcare sectors.
- To assess adherence to guideline-based key performance indicators (KPIs) for RM care, including investigations, treatments, and supportive care.
Main Methods:
- An online survey was administered to clinical leads and specialists in public (RM and fertility clinics) and private fertility clinics.
- The survey, conducted from November 2021 to February 2022, assessed care structure, investigations, treatments, counselling, supportive care, and outcomes.
- Data were analyzed based on adapted guideline-based KPIs for RM.
Main Results:
- A 73% response rate was achieved, with significant variation across provider types (Public RM care: 95%, Public fertility: 40%, Private fertility: 33%).
- Access to fertility expertise was limited in public RM clinics (39%). Investigations and treatments largely followed guidelines, but uncertainty existed regarding immunotherapies.
- Significant educational needs were identified in fertility counselling and supportive care resources. Clinical outcomes were rarely audited (9%).
Conclusions:
- Greater engagement with the private sector is crucial for unifying care and ensuring standardized, evidence-based practices for RM and infertility.
- Mandatory audit and outcomes reporting are essential for quality improvement in RM care.
- Incorporating the lived experiences of service users is vital for informing and improving current care structures.
More Related Videos
08:29Author Spotlight: Multiplex Immunohistochemistry for Understanding Immune Regulation by Uterine NK Cells in Pregnancy
Published on: October 25, 2024
07:46Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells
Published on: October 13, 2023
Related Concept Videos
Infertility in Females
Endometriosis, a condition characterized by abnormal growth of...
Infertility in Males