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Polylactic Acid-Based Biomaterials in Wound Healing: A Systematic Review
Hui Ling Chen1, Joanne Wai Yee Chung, Vincent Chun Man Yan
1Hui Ling Chen, BS is Master of Philosophy Student, School of Nursing and Health Studies, Hong Kong Metropolitan University. Joanne Wai Yee Chung, PhD, RN, is Professor, Hong Kong Nang Yan College of Higher Education. Vincent Chun Man Yan, MSc, is Senior Lecturer, School of Nursing and Health Studies, Hong Kong Metropolitan University. Thomas Kwok Shing Wong, PhD, RN, is Professor, Hong Kong Nang Yan College of Higher Education. The authors have disclosed no financial relationships related to this article. Submitted August 18, 2022; accepted in revised form November 4, 2022; published ahead of print July 24, 2023.
Polylactic acid (PLA)-based biomaterials show promise for wound healing and infection prevention due to their biocompatibility and biodegradability. These advanced materials appear safe for use, though further research is needed for wider wound care applications.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Polymer Chemistry
Background:
- Polylactic acid (PLA) is a biodegradable and biocompatible polymer with potential applications in biomedical fields.
- Effective wound healing and infection prevention are critical challenges in healthcare.
- Existing biomaterials for wound care have limitations that necessitate the development of novel alternatives.
Approach:
- A systematic review was conducted, analyzing 14 studies published between 2000 and 2021.
- Data from multiple databases (PubMed, MEDLINE, Cochrane Library, etc.) were synthesized.
- Information on wound type, PLA material, techniques, and outcomes was extracted and analyzed.
Key Points:
- PLA biomaterials may enhance wound healing via improved tissue repair, collagen synthesis, and angiogenesis.
- Their inherent biocompatibility, biodegradability, and moisture management contribute to efficacy.
- Both native PLA and PLA blends exhibit potential antibacterial properties, warranting further investigation.
- No severe adverse events or significant cytotoxicity were reported, suggesting a favorable safety profile.
Conclusions:
- Polylactic acid (PLA)-based biomaterials show promise as effective wound dressing materials.
- Their inherent properties support wound healing and infection prevention.
- Additional research is necessary to fully establish the broader applicability of PLA-based biomaterials in comprehensive wound care strategies.
