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Vascular changes in human leishmaniasis: a light microscope and immunohistological study.

B Veress, A M el Hassan

    Annals of Tropical Medicine and Parasitology
    |April 1, 1986
    PubMed
    Summary

    Vascular alterations, including vasculitis and immune complex deposition, were observed in human leishmaniasis. These changes in cutaneous, mucosal, and visceral leishmaniasis highlight immune complexes as key drivers of vascular damage.

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    Area of Science:

    • Medical Microbiology
    • Immunology
    • Pathology

    Background:

    • Leishmaniasis is a significant parasitic disease with diverse clinical manifestations.
    • Vascular involvement in leishmaniasis pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate vascular alterations in human cutaneous, mucosal, and visceral leishmaniasis.
    • To elucidate the role of immune complexes in leishmaniasis-associated vasculopathy.

    Main Methods:

    • Histopathological examination of tissue samples from leishmaniasis patients.
    • Immunoperoxidase staining to detect immunoglobulin deposition (IgG, IgA).

    Main Results:

    • Cutaneous and mucosal leishmaniasis showed vasculitis with fibrinoid necrosis and thrombi in arteries and veins.

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  • Visceral leishmaniasis presented with subendothelial edema, hyalinosis, and intimal proliferation in small arteries.
  • IgG and IgA were found within diseased vessels in cutaneous leishmaniasis lesions.

    • Conclusions:

    • Immune complex formation is implicated in the vascular lesions observed in leishmaniasis.
    • Distinct vascular pathologies occur in different forms of leishmaniasis, driven by immune complex mechanisms.