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Related Experiment Video

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Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model
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Transspinal Focused Ultrasound Suppresses Spinal Reflexes in Healthy Rats.

Weiguo Song1, Naveen Jayaprakash1, Nafiseh Saleknezhad1

  • 1Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, NY, USA.

Neuromodulation : Journal of the International Neuromodulation Society
|August 2, 2023
PubMed
Summary
This summary is machine-generated.

Trans-spinal focused ultrasound (tsFUS) reversibly suppresses spinal reflexes in rats. This noninvasive neuromodulation technique shows potential for treating conditions like spasticity and pain.

Keywords:
H-reflexnoninvasive neuromodulationpaintransspinal focused ultrasound stimulationwindup

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Neuromodulation

Background:

  • Low-intensity focused ultrasound (FUS) is a noninvasive neuromodulation technique with advanced resolution and penetration.
  • While FUS effectively modulates brain and peripheral nervous system circuits, its impact on spinal circuits remains largely unexplored.

Purpose of the Study:

  • To investigate the effects of trans-spinal focused ultrasound (tsFUS) on spinal reflexes in healthy rats.
  • To determine the safety and efficacy of tsFUS for spinal cord neuromodulation.

Main Methods:

  • Trans-spinal focused ultrasound (tsFUS) was applied to different spinal segments in anesthetized rats for 1 minute.
  • Monosynaptic H-reflex, polysynaptic flexor reflex, and withdrawal reflex were measured before, during, and after tsFUS application.

Main Results:

  • tsFUS reversibly suppressed the H-reflex in a manner dependent on spinal segment, acoustic pressure, and pulse-repetition frequency (PRF).
  • High PRF tsFUS enhanced homosynaptic depression of the H-reflex and suppressed flexor reflex windup associated with C-afferent fibers.
  • tsFUS increased withdrawal reflex latency and did not cause neuronal loss in the spinal cord.

Conclusions:

  • Trans-spinal focused ultrasound (tsFUS) demonstrates a reversible suppressive effect on spinal reflexes.
  • tsFUS presents a safe and potentially effective neuromodulation strategy for spinal cord disorders characterized by hyperreflexia, such as spasticity and pain syndromes.