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Related Concept Videos

Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Somatic to iPS Cell Reprogramming01:29

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Introduction to Nuclear Reprogramming01:14

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Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Related Experiment Video

Updated: Jul 20, 2025

Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes
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Cell Reprogramming Techniques: Contributions to Cancer Therapy.

Tongtong Guo1, Qi Wei2

  • 1College of Life Science, Northwest University, Xi'an, China.

Cellular Reprogramming
|August 2, 2023
PubMed
Summary
This summary is machine-generated.

Cell reprogramming technology, including induced pluripotent stem cells (iPSCs), is revolutionizing cancer research and therapy. This approach aids in modeling cancer, developing drugs, and enhancing immunotherapies by reprogramming cells.

Keywords:
cancercancer modelingiPSCimmunotherapy

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Area of Science:

  • Biomedical Engineering
  • Stem Cell Biology
  • Cancer Research

Background:

  • Induced pluripotent stem cells (iPSCs) are crucial for regenerative medicine and disease modeling.
  • iPSCs derived from cancer patients offer insights into cancer progression and drug development.
  • Patient-derived iPSC-induced immune cells address immune rejection in cancer therapy.

Purpose of the Study:

  • To review recent advancements in cell reprogramming technology for human cancer research.
  • To highlight the application of reprogramming in cancer immunotherapy and its benefits.
  • To summarize malignant phenotype changes during cancer cell reprogramming and differentiation.

Main Methods:

  • Utilizing patient-derived iPSCs for cancer modeling and drug testing.
  • Generating iPSC-induced immune cells (T, NK, macrophages) for enhanced cancer immunotherapy.
  • Applying reprogramming to revert cancer cells to a benign phenotype via epigenetic modification.

Main Results:

  • iPSCs facilitate the study of early cancer progression and molecular mechanisms.
  • iPSC-derived immune cells improve therapeutic efficiency and reduce immune rejection.
  • Reprogramming can reverse malignant phenotypes by altering epigenetic inheritance.

Conclusions:

  • Cell reprogramming technology shows significant promise in cancer research and treatment.
  • iPSC applications in immunotherapy and differentiation therapy are expanding.
  • Understanding reprogramming-induced cellular changes is key to advancing cancer care.