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Related Concept Videos

Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

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Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
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Related Experiment Video

Updated: Jul 20, 2025

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke
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Acetylglutamine Differentially Associated with First-Time Versus Recurrent Stroke.

Naruchorn Kijpaisalratana1,2,3,4, Zsuzsanna Ament1,4, Amit Patki5

  • 1Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Translational Stroke Research
|August 2, 2023
PubMed
Summary
This summary is machine-generated.

Recurrent stroke risk remains high. This study identified acetylglutamine as a key metabolite associated with recurrent stroke, independent of traditional risk factors, offering potential new prevention strategies.

Keywords:
AcetylglutamineMetabolomicsRecurrent strokeRisk factors

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Area of Science:

  • Neuroscience
  • Metabolomics
  • Epidemiology

Background:

  • Approximately 25% of strokes occur in individuals with a history of stroke.
  • Despite advances in secondary stroke prevention, the long-term risk of recurrent stroke has not decreased.
  • Identifying novel risk markers for recurrent stroke is crucial for improving patient outcomes.

Purpose of the Study:

  • To identify specific metabolite risk markers associated with recurrent stroke.
  • To investigate the differential association of metabolites with first-time versus recurrent stroke.

Main Methods:

  • Targeted metabolomic profiling of 162 plasma metabolites using liquid chromatography-tandem mass spectrometry.
  • Analysis within a stroke case-cohort study nested in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study.
  • Weighted Cox proportional hazard models with interaction terms to assess metabolite associations with prior stroke status.

Main Results:

  • Thirteen candidate metabolites showed a significant interaction with prior stroke status (p < 0.05).
  • Acetylglutamine surpassed the Bonferroni adjusted p-value threshold for interaction (p = 5.78 × 10-5).
  • Acetylglutamine was significantly associated with recurrent stroke (HR = 2.27) but not first-time stroke (HR = 0.96), independent of traditional risk factors.

Conclusions:

  • Acetylglutamine is a novel metabolite risk marker specifically associated with recurrent stroke.
  • This finding is independent of established stroke risk factors, suggesting a distinct pathophysiological role.
  • Further research is needed to understand the mechanisms linking acetylglutamine to recurrent stroke risk.