Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

6.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
6.9K
Clinical Trials: Overview01:11

Clinical Trials: Overview

3.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.0K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Application of a translational research platform to unveil efficacy signals and mechanisms of resistance of FGFR inhibitors in multiple FGFR-altered solid tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Randomized phase 2 trial of CPX-351 vs. CLAG-M (cladribine, cytarabine, G-CSF, and mitoxantrone) for medically unfit adults with acute myeloid leukemia or other high-grade myeloid neoplasms.

Leukemia·2026
Same author

Perspectives From an Expert-Guided Discussion on Maximizing the Research Potential of Small Biopsy Tissue.

JCO precision oncology·2026
Same author

Addressing Biases in Analysis of Time of Infusion: NCI/SWOG Trial S1404 Among Participants With High-Risk Resectable Melanoma Who Received Adjuvant Anti-PD-1 Therapy.

JCO oncology practice·2026
Same author

Phase II Study of Adavosertib in Patients With Tumors Containing BRCA1 and BRCA2 Mutations: Results From the NCI-MATCH ECOG-ACRIN Cancer Research Group (EAY131) Subprotocol Z1I.

JCO precision oncology·2026
Same author

Cancer chemo-immunotherapy: time will tell.

Cancer immunology research·2026

Related Experiment Video

Updated: Jul 20, 2025

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

11.9K

The New NCI Precision Medicine Trials.

Lyndsay N Harris1, Charles D Blanke2, Harry P Erba3

  • 1Division of Cancer Treatment and Diagnosis, NCI, Bethesda, Maryland.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|August 2, 2023
PubMed
Summary

Master protocols like NCI-MATCH advanced precision oncology. Newer NCI trials (ComboMATCH, iMATCH, myeloMATCH) explore targeted therapy combinations to improve metastatic disease control in cancer.

More Related Videos

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.2K
In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

1.8K

Related Experiment Videos

Last Updated: Jul 20, 2025

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

11.9K
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.2K
In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

1.8K

Area of Science:

  • Oncology
  • Precision Medicine
  • Clinical Trial Design

Background:

  • Master protocols, including basket, umbrella, and platform trials, have gained prominence for studying precision medicine in oncology over the past decade.
  • First-generation trials, such as NCI-MATCH (Molecular Analysis for Therapy Choice), demonstrated the feasibility of large-scale targeted therapy research from both laboratory and clinical viewpoints.
  • Single-agent targeted therapies have demonstrated limited efficacy in controlling metastatic cancer, even with precise drug-target matching.

Purpose of the Study:

  • To introduce and discuss the design and necessary infrastructure for three second-generation precision medicine trials initiated by the NCI.
  • To address the limitations of single-agent targeted therapies by exploring newer approaches involving combinations of targeted therapies or targeted therapy with standard treatments.
  • To advance the field of precision oncology by developing innovative clinical trial designs for combination therapies.

Main Methods:

  • Discussion of the design principles behind the new NCI-led precision medicine trials: ComboMATCH, iMATCH, and myeloMATCH.
  • Exploration of the infrastructure requirements for implementing these complex, multi-arm, multi-stage trial designs.
  • Focus on the strategic shift towards combination therapies within a master protocol framework.

Main Results:

  • The abstract does not present specific results but discusses the rationale and design of new trials.
  • Highlights the transition from first-generation single-agent targeted therapy trials to second-generation combination therapy trials.
  • Emphasizes the feasibility and necessity of advanced master protocol designs for future precision oncology research.

Conclusions:

  • Second-generation precision medicine trials are essential to overcome the limitations of single-agent therapies in metastatic cancer.
  • The NCI's new trials (ComboMATCH, iMATCH, myeloMATCH) represent a significant step forward in master protocol design for combination therapies.
  • Effective infrastructure and innovative trial designs are crucial for the successful implementation of large-scale precision oncology studies.