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[Value of plasma fibronectin in pediatric intensive care]
Insights
Plasma fibronectin levels are significantly lower in critically ill children with severe infections. Measuring fibronectin offers valuable diagnostic and prognostic insights for pediatric severe infections.
Area of Science:
- Pediatric Critical Care Medicine
- Clinical Biochemistry
- Infectious Diseases
Abstract:
This work was undertaken to demonstrate the pathophysiologic and prognostic value of plasma fibronectin measurement in critically ill children. Fibronectin was measured by laser-nephelometry in 25 children (group 1) whose ages ranged from 1 month to 12 years (mean: 13.8 months). All presented with severe infections. The control group consisted of 16 children with various benign disorders, whose ages ranged from 3 months to 13 years (mean: 3.6 years). Fibronectin plasma levels in group 1 (mean: 0.16 g/l +/- 0.08) and in the control group (mean: 0.28 +/- 0.10) were significantly different (alpha less than 0.001). The initial concentration and the kinetics of this protein during evolution seem to have a good diagnostic and prognostic value in severe infections in children.