Related Experiment Video

Updated: Jul 20, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

454

Non-coding RNAs, cancer treatment and cardiotoxicity: A triad of new hope

Rishabh Mittal1, Sarath Krishnan M P1, Rahul Saxena1

  • 1Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India.

Cancer Treatment and Research Communications
|August 2, 2023
PubMed

Insights

Cardio-oncology addresses cardiovascular disease (CVD) in cancer patients and survivors. Non-coding RNAs (ncRNAs) are key to diagnosing, treating, and preventing CVD during cancer therapy.

Area of Science:

  • Cardio-oncology
  • Molecular Biology
  • Oncology

Background:

  • Global health trends show rising non-communicable diseases, including cancer and cardiovascular diseases (CVD).
  • Increased life expectancy leads to a higher burden of chronic conditions, including cancer survivors facing cardiovascular complications.
  • Anticancer therapies can cause unintended cardiovascular toxicity, increasing morbidity and mortality.

Approach:

  • This review assesses cardiovascular risk in cancer survivors.
  • It investigates the role of non-coding RNAs (ncRNAs) in CVD among patients undergoing cancer treatment.
  • The review explores ncRNAs' utility in diagnosing, treating, and preventing CVD in cancer survivors.

Key Points:

  • Non-coding RNAs (ncRNAs) are crucial in cardio-oncology for early diagnosis, prognosis, and therapeutics.
  • Understanding cancer therapy-related cardiovascular disease pathogenesis and ncRNAs is vital.
  • ncRNAs offer potential for improved diagnostic, therapeutic, and preventive strategies.

Conclusions:

  • Minimizing cardiovascular side effects of cancer treatment improves patient outcomes.
  • ncRNAs play a significant role in managing cardiovascular health in cancer patients.
  • This review provides insights into the interplay between cancer and CVD for better patient care.
Keywords:
Antineoplastic agentsCancerCardio-oncologyCardiotoxicityCardiovascular diseasencRNAs

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