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Updated: Jul 20, 2025
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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
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Neoadjuvant therapy in non-small cell lung cancer
Christopher Grant1, Garo Hagopian1, Misako Nagasaka2
1Department of Medicine, University of California Irvine School of Medicine, Orange, CA, USA.
Critical Reviews in Oncology/Hematology
|August 2, 2023
Summary
Neoadjuvant nivolumab plus chemotherapy is now FDA-approved for resectable non-small cell lung cancer (NSCLC). Ongoing trials explore new neoadjuvant combinations for improved lung cancer treatment outcomes.
Area of Science:
- Oncology
- Immunotherapy
- Thoracic Surgery
Background:
- Historically, stages I-III non-small cell lung cancer (NSCLC) primarily involved surgery and chemotherapy.
- The landscape of NSCLC treatment is evolving with novel therapeutic strategies.
Purpose of the Study:
- To review pivotal clinical trials in neoadjuvant NSCLC treatment.
- To discuss emerging neoadjuvant therapies, including immunotherapy and targeted treatments.
- To analyze the potential benefits and challenges of current NSCLC clinical trials.
Main Methods:
- Review of existing clinical trial data for neoadjuvant NSCLC therapies.
- Analysis of ongoing clinical trials investigating novel treatment combinations.
- Evaluation of targeted therapies for specific driver mutations in NSCLC.
Main Results:
- Checkmate-816 established FDA approval for neoadjuvant nivolumab and chemotherapy in resectable NSCLC.
- Multiple ongoing trials are assessing combinations of chemotherapy, immunotherapy, and targeted agents.
- Emerging strategies aim to improve outcomes for early-stage NSCLC patients.
Conclusions:
- Neoadjuvant immunotherapy combined with chemotherapy represents a significant advancement for resectable NSCLC.
- Future research focuses on optimizing neoadjuvant treatment regimens, including targeted therapies.
- Ongoing trials hold promise for enhancing treatment efficacy and patient benefit in NSCLC.
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