Related Experiment Video

Updated: Jul 20, 2025

Rescue of Recombinant Newcastle Disease Virus from cDNA
10:55

Rescue of Recombinant Newcastle Disease Virus from cDNA

Published on: October 11, 2013

19.4K

Multifunctionality of matrix protein in the replication and pathogenesis of Newcastle disease virus: A review

Zhiqiang Duan1, Qianyong Zhang1, Menglan Liu1

  • 1Key Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, China; College of Animal Science, Guizhou University, Guiyang, China.

International Journal of Biological Macromolecules
|August 2, 2023
PubMed

Insights

The Newcastle disease virus (NDV) matrix (M) protein is crucial for viral assembly and pathogenesis. This review consolidates research on M protein

Area of Science:

  • Virology
  • Molecular Biology
  • Immunology

Background:

  • The matrix (M) protein of Newcastle disease virus (NDV) is essential for viral structure and replication.
  • M protein influences NDV pathotypes and interacts with host cellular proteins, impacting viral pathogenicity.
  • Existing knowledge on NDV M protein is fragmented, necessitating a comprehensive review.

Purpose of the Study:

  • To consolidate and update research on the structural features, virulence, and nucleocytoplasmic transport of NDV M protein.
  • To elucidate the functions of M protein and its interactions with cellular proteins in viral lifecycle.
  • To provide insights for developing antiviral strategies against NDV.

Main Methods:

  • Literature review and synthesis of existing research on NDV M protein.
  • Analysis of studies on M protein structure, function, and interactions.
  • Compilation of data on M protein's role in viral replication and pathogenesis.

Main Results:

  • NDV M protein is a nuclear-cytoplasmic trafficking protein vital for viral assembly and budding.
  • M protein interactions with cellular proteins are critical for viral RNA/protein synthesis, immune evasion, and release.
  • M protein significantly influences NDV virulence and pathotype.

Conclusions:

  • A comprehensive understanding of NDV M protein's functions is essential for controlling NDV.
  • Targeting M protein-host interactions offers potential antiviral strategies.
  • Further research on M protein will advance NDV pathogenesis and therapeutic development.
Keywords:
Matrix proteinNewcastle disease virusPathogenesis

More Related Videos

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses12:20

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Published on: December 29, 2015

21.5K
Production of High-Titer Recombinant Newcastle Disease Virus from Allantoic Fluid07:24

Production of High-Titer Recombinant Newcastle Disease Virus from Allantoic Fluid

Published on: May 25, 2022

3.7K

Related Concept Videos

Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.2K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
56
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
61
Subviral Agents01:29

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
42
Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.4K
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.5K