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Management of hepatitis D in general practice

Carmela Cosentino1, Daniel Clayton-Chubb2, John S Lubel3

  • 1BBiomedSc, MD, Junior Doctor, Basic Physician Trainee at Alfred Health, Department of Gastroenterology and Hepatology, Alfred Health, Melbourne, Vic.

Australian Journal of General Practice
|August 2, 2023
PubMed

Insights

Hepatitis D virus (HDV) coinfection accelerates liver disease in hepatitis B patients. Routine HDV screening and prompt referral for treatment are crucial for managing chronic hepatitis B and preventing severe outcomes.

Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Hepatitis D virus (HDV) coinfection accelerates liver disease progression in individuals with chronic hepatitis B (CHB).
  • HDV infection is associated with increased risks of cirrhosis and hepatocellular carcinoma.
  • Approximately 4% of Australians with CHB are coinfected with HDV, with potential underdiagnosis.

Purpose of the Study:

  • To emphasize the importance of screening for HDV in CHB patients.
  • To provide general practitioners (GPs) with an overview of HDV diagnosis and treatment.
  • To reduce liver-related morbidity and mortality in CHB and HDV coinfected individuals.

Main Methods:

  • Literature review and clinical guideline synthesis.
  • Focus on diagnostic approaches and therapeutic strategies for HDV.
  • Emphasis on the role of GPs in patient management.

Main Results:

  • Routine HDV screening is recommended for all CHB patients due to diverse risk factors.
  • GPs play a critical role in identifying and initiating the diagnostic process for HDV.
  • Prompt referral to specialists is advised for considering HDV therapy.

Conclusions:

  • Early detection and management of HDV in CHB patients are essential.
  • Enhanced GP awareness and screening protocols can improve patient outcomes.
  • Addressing HDV underdiagnosis is vital for public health in Australia.
Abstract

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