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Impaired Dynamic Cerebral Autoregulation in Patients With Cerebral Venous Sinus Thrombosis: Evaluation Using

Songwei Chen1, Hongxiu Chen1, Jiangang Duan2

  • 1Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Diagnostic Center of Vascular Ultrasound, Beijing, China; Center of Vascular Ultrasonography, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.

Ultrasound in Medicine & Biology
|August 2, 2023
PubMed

Insights

Cerebral venous sinus thrombosis (CVST) impairs dynamic cerebral autoregulation (dCA) and neurovascular coupling (NVC) in the posterior cerebral artery (PCA). These findings highlight potential neurological deficits in CVST patients affecting brain blood flow regulation.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Cerebrovascular Physiology

Background:

  • Cerebral venous sinus thrombosis (CVST) is a condition that can affect brain function.
  • Previous research on CVST has primarily focused on the middle cerebral artery (MCA), with limited investigation into the posterior cerebral artery (PCA).
  • Dynamic cerebral autoregulation (dCA) and neurovascular coupling (NVC) are crucial for maintaining stable cerebral blood flow.

Purpose of the Study:

  • To investigate the impact of CVST on dCA and NVC of the MCA and PCA.
  • To assess dCA during silent reading.
  • To evaluate NVC using visual stimulation.

Main Methods:

  • Sixty CVST patients and 30 controls were enrolled.
  • Non-invasive transcranial Doppler was used to measure beat-to-beat blood pressure and cerebral blood flow velocity in the MCA and PCA during silent reading.
  • NVC was assessed through periodic eye-opening and closing, with visual stimulation provided by silently reading Chinese tourism materials.
  • dCA was determined using transfer function analysis.

Main Results:

  • CVST patients showed a lower very low frequency phase in dCA of the PCA during silent reading compared to controls (p=0.047).
  • In NVC, CVST patients exhibited lower cerebrovascular conductance and visually evoked flow response indexes than controls (p=0.017 and p=0.019, respectively).

Conclusions:

  • CVST significantly impairs dCA and NVC of the PCA during silent reading.
  • These findings suggest that CVST can lead to compromised cerebral blood flow regulation in the posterior circulation.
Abstract

Keywords:
Cerebral autoregulationDopplerNeurovascular couplingSilent readingSinus thrombosisTranscranialTransfer function analysisUltrasound

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