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APP family member dimeric complexes are formed predominantly in synaptic compartments

Sandra Schilling1, Alexander August1, Mathieu Meleux1

  • 1Department of Human Biology and Human Genetics, University of Kaiserslautern, 67663, Kaiserslautern, Germany.

Cell & Bioscience
|August 2, 2023
PubMed
Summary

Alzheimer's disease (AD) research reveals that amyloid precursor protein (APP) dimerization decreases in AD patients. Loss of full-length APP dimers may correlate with synaptic loss in AD progression.

Keywords:
APLP1APLP2Alzheimer’s diseaseAmyloid precursor proteinBlue Native gelsDimerizationSynaptosomes

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