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Engineering Nanotrap Hydrogel for Immune Modulation in Wound Healing
Xiguang Yang1, Dandan Guo1, Xiaotian Ji1
1Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
Macromolecular Rapid Communications
|August 3, 2023
Summary
Engineered hydrogels with telodendrimer nanotrap (TD NT) platforms can scavenge inflammatory cytokines. This approach offers a promising topical treatment for abnormal wound healing by restoring immune balance.
Area of Science:
- Biomaterials Science
- Immunology
- Wound Healing Research
Background:
- Imbalanced immune regulation disrupts normal wound healing, leading to chronic wounds or scarring.
- Controlling excessive inflammatory factors is crucial for restoring immune homeostasis and promoting healing.
Purpose of the Study:
- To develop a versatile telodendrimer (TD) nanotrap (NT) hydrogel platform for topical immune modulation.
- To investigate the efficacy of TD NT hydrogel in scavenging cytokines and attenuating inflammation.
Main Methods:
- Conjugation of TD NTs into a size-exclusive biocompatible hydrogel resin for cytokine scavenging.
- Fine-tuning TD NT density and charge to control hydrogel properties and optimize cytokine capture.
- Evaluating hydrogel performance in vitro using cell culture medium and in vivo using a mouse model of local inflammation.
Main Results:
- Hydrogel with reduced TD NT density demonstrated enhanced protein/cytokine adsorption capacity and faster kinetics.
- Positively charged TD NT hydrogel effectively removed negatively charged proinflammatory cytokines.
- Negatively charged TD NT hydrogel efficiently removed positively charged anti-inflammatory cytokines.
- TD NT hydrogel successfully constrained local inflammation induced by lipopolysaccharide (LPS) injection in mice.
Conclusions:
- Engineered TD NT hydrogel serves as an effective platform for topical immune modulation.
- This technology shows significant potential for treating inflammatory conditions and promoting normal wound healing.
