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Related Concept Videos

Contact-dependent Signaling01:19

Contact-dependent Signaling

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Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
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IP3/DAG Signaling Pathway01:11

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Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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Regulation of Expression at Multiple Steps01:23

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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Pulse regulation involves physiological mechanisms that ensure adequate blood flow throughout the body. The heartbeat, regulated by the autonomic nervous system, is influenced by hormonal balance, physical activity, and emotional state.
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Related Experiment Video

Updated: Jul 20, 2025

Author Spotlight: An Efficient and Robust Software for Automated Fusion of Multiple Preclinical Imaging Modalities
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Author Spotlight: An Efficient and Robust Software for Automated Fusion of Multiple Preclinical Imaging Modalities

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Protocol Registration.

Vaibhav Sahni1

  • 1Private Practice, New Delhi, India.

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|August 3, 2023
PubMed
Summary
This summary is machine-generated.

Prospective registration of systematic reviews is encouraged. Protocol registration information can improve the robustness of systematic review reports, aligning with PRISMA guidelines.

Keywords:
PRISMAmeta-analysissystematic review

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Area of Science:

  • Systematic review methodology
  • Research integrity

Background:

  • Prospective registration of systematic reviews is a recommended practice.
  • Adherence to PRISMA guidelines is crucial for high-quality systematic reviews.

Discussion:

  • Documenting protocol registration enhances transparency in systematic reviews.
  • This practice potentially strengthens the reliability and validity of reported findings.

Key Insights:

  • Protocol registration is integral to PRISMA standards.
  • Reporting registration details improves systematic review robustness.

Outlook:

  • Encouraging prospective registration can elevate research standards.
  • Future systematic reviews should prioritize and report protocol registration.