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Updated: Jul 20, 2025
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In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila
Published on: November 27, 2016
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Noncoding RNAs in apoptosis: identification and function.
Özge Tüncel1, Merve Kara1, Bilge Yaylak1
1Non-coding RNA Laboratory, Department of Molecular Biology and Genetics, Faculty of Science, İzmir Institute of Technology, İzmir, Turkey.
Turkish Journal of Biology = Turk Biyoloji Dergisi
|August 3, 2023
Summary
Apoptosis, crucial for homeostasis, is regulated by noncoding RNAs like microRNAs, circular RNAs, and long noncoding RNAs. Dysregulation of apoptosis contributes to diseases like cancer and neurodegeneration.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- Apoptosis is a fundamental cellular process essential for maintaining organismal homeostasis.
- Disruptions in apoptotic pathways are implicated in various diseases, including cancer and neurodegenerative disorders.
- Regulatory mechanisms, initially focused on protein-coding genes, are now expanding to include noncoding RNAs.
Purpose of the Study:
- To provide a comprehensive overview of apoptosis.
- To discuss methods for detecting apoptosis.
- To explore the roles of microRNAs, circular RNAs, and long noncoding RNAs in regulating apoptosis.
Main Methods:
- Literature review of apoptosis.
- Analysis of transcriptomics data.
- Review of studies on noncoding RNA functions in apoptosis.
Main Results:
- Noncoding RNAs, including microRNAs, circular RNAs, and long noncoding RNAs, are significant regulators of apoptosis.
- These noncoding RNAs modulate diverse biochemical processes beyond apoptosis.
- Detection methods for apoptosis are crucial for understanding its role in health and disease.
Conclusions:
- Noncoding RNAs represent a critical layer of apoptosis regulation.
- Understanding noncoding RNA involvement in apoptosis is vital for disease research.
- Further investigation into noncoding RNAs will advance our knowledge of cellular homeostasis and disease pathogenesis.
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