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Updated: Jul 20, 2025

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
Published on: November 2, 2018
NF-kB's contribution to B cell fate decisions
Caitlyn Guldenpfennig1,2, Emma Teixeiro1,2, Mark Daniels1,2
1Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, United States.
Abstract:
NF-κB signaling is essential to an effective innate and adaptive immune response. Many immune-specific functional and developmental outcomes depend in large on NF-κB. The formidable task of sorting out the mechanisms behind the regulation and outcome of NF-κB signaling remains an important area of immunology research. Here we briefly discuss the role of NF-κB in regulating cell fate decisions at various times in the path of B cell development, activation, and the generation of long-term humoral immunity.
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