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Migraine and risk of rheumatoid arthritis: A systematic review and meta-analysis of observational studies

Dachen Tian1, Xuan Zhao2, Zhaoteng Ning3

  • 1Department of Critical Care Medicine, Linyi People's Hospital, Linyi, Shandong, China.

Heliyon
|August 3, 2023
PubMed
Abstract

Insights

Migraine may increase the risk of developing rheumatoid arthritis (RA). This meta-analysis found migraine sufferers have a higher chance of RA onset, but more research is needed for confirmation.

Area of Science:

  • Rheumatology
  • Neurology
  • Epidemiology

Background:

  • The potential link between migraine and rheumatoid arthritis (RA) risk is debated.
  • Investigating migraine as a risk factor for RA onset is crucial for understanding disease etiology.

Purpose of the Study:

  • To systematically review and meta-analyze existing literature to determine the association between migraine and the risk of developing rheumatoid arthritis (RA).

Main Methods:

  • A comprehensive literature search was conducted across PubMed, EMBASE, Web of Science, and Scopus databases up to July 2022.
  • Included observational studies were analyzed using a random-effects or fixed-effects model for pooled effect size estimation.

Main Results:

  • Five studies, including 3 case-control and 2 cohort studies, were identified from 2345 records.
  • Migraineurs demonstrated a significantly increased risk of developing RA, with a pooled adjusted effect estimate of 1.94 (95% CI: 1.74-2.17; p < 0.01).

Conclusions:

  • Migraine is suggested as a potential risk factor for rheumatoid arthritis (RA).
  • The findings indicate a statistically significant association, but require cautious interpretation due to study limitations.
  • Further rigorous research with larger sample sizes is recommended to validate these findings and clarify the relationship.
Keywords:
Meta-analysisMigraineRheumatoid arthritis

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