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Enhancing bone formation using absorbable AZ31B magnesium alloy membranes during distraction osteogenesis: A new
Guiran Zhao1, Shu Wang2, Guijun Wang3
1Department of Oral and Maxillofacial Surgery. First Affiliated Hospital of Jinzhou Medical University, Jinzhou City, Liaoning Province, China.
Heliyon
|August 3, 2023
Summary
Absorbable AZ31B magnesium alloy membranes significantly enhanced regenerated bone quantity and quality compared to collagen membranes in a canine mandibular distraction osteogenesis model. AZ31B membranes supported bone formation and reduced width reduction.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Orthopedic Surgery
Background:
- Distraction osteogenesis requires effective gap management for optimal bone regeneration.
- Absorbable membranes are utilized to support bone healing and guide tissue regeneration.
- Comparing different biomaterials is crucial for advancing orthopedic and maxillofacial procedures.
Purpose of the Study:
- To evaluate the efficacy of absorbable AZ31B magnesium alloy membranes versus collagen membranes in enhancing regenerated bone quality and quantity.
- To assess the impact of these membranes on mandibular distraction osteogenesis in a canine model.
Main Methods:
- Fifteen dogs underwent mandibular distraction osteogenesis, with experimental sides receiving either AZ31B or collagen membranes.
- Control animals did not undergo surgery.
- Regenerated bone was analyzed using cone-beam computed tomography (CBCT) and micro-CT after two months.
Main Results:
- AZ31B membranes promoted greater bone formation than collagen membranes.
- Significant differences were observed in width reduction (AZ31B: 0.11 cm vs. Collagen: 0.42 cm) and trabecular thickness (AZ31B: 0.338 cm vs. Collagen: 0.178 cm).
- Collagen membranes were fully absorbed, while AZ31B membranes showed surface irregularities.
Conclusions:
- AZ31B magnesium alloy membranes are biocompatible and absorbable barriers that support osteoprogenitor proliferation.
- AZ31B membranes effectively maintain distraction gaps and enhance bone regeneration compared to collagen membranes.
- These findings suggest AZ31B's potential for improving outcomes in distraction osteogenesis.
