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Peripheral T-cell activation, Th17 cells, regulatory T-cells, and aortic aneurysm in people with HIV

Malene Hove-Skovsgaard1, Julie Høgh1, Michael Huy Cuong Pham2

  • 1Department of Infectious Diseases.

AIDS (London, England)
|August 3, 2023
PubMed

Here, we investigate if peripheral T-cell activation and proportion of Th17 and T-regulatory cells (Tregs) are associated with aortic aneurysm or aortic diameter in people with HIV. Aorta was examined by computed tomography scans and T-cells by flow cytometry in 428 participants, and aortic aneurysm was found in 32 participants. None of the T-cell subsets were associated with aortic aneurysm, but activated T-cells and Tregs had opposite association to aorta diameter indicating an inverse impact.

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