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Updated: Jul 20, 2025
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Harnessing neutrophil plasticity for HCC immunotherapy.
Erik Ramon-Gil1,2, Daniel Geh1,2, Jack Leslie1,2
1Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, U.K.
Tumor-associated neutrophils (TANs) in hepatocellular carcinoma (HCC) show surprising heterogeneity. Understanding these diverse neutrophil functions is key to developing novel immunotherapies for HCC.
Area of Science:
- Immunology
- Oncology
- Cell Biology
Background:
- Neutrophils were historically viewed as a uniform cell type.
- Tumor-associated neutrophils (TANs) in hepatocellular carcinoma (HCC) are often considered pro-tumorigenic.
- Recent advances reveal significant heterogeneity within TANs in the HCC tumor microenvironment.
Conclusions:
- Neutrophil heterogeneity in HCC presents a potential therapeutic target.
- Exploiting diverse neutrophil functions may enhance immunotherapy outcomes.
- Targeting and reprogramming neutrophils are emerging strategies for HCC treatment.
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