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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

35
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Global perspective of kidney diseases: Challenges and changes.

Masaomi Nangaku1

  • 1Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.

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Chronic kidney disease (CKD) poses a global health challenge. Developing new drugs requires a guided approach to translational research, especially for low-income countries needing kidney replacement therapy.

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Area of Science:

  • Nephrology
  • Drug Development
  • Public Health

Background:

  • Chronic kidney disease (CKD) is a significant global health concern requiring continuous prevention and treatment efforts.
  • Kidney replacement therapy funding is critically needed in low-income countries (LICs) and lower-middle-income countries (LMICs).
  • A multisectoral approach is essential to address the worldwide burden of kidney disease.

Purpose of the Study:

  • To provide guidance on the optimal management of translational animal studies for developing new kidney disease drugs.
  • To connect global kidney experts and foster collaboration in drug development.
  • To address the residual risks and unmet needs in CKD patient care through novel therapeutics.

Main Methods:

  • Convened a consensus meeting titled 'TRANSFORM; TRAnslational Nephrology Science FOR new Medications'.
  • Brought together experts from the global kidney community.
  • Focused on optimizing translational animal studies for drug development.

Main Results:

  • Established guidance for effective translational animal studies in nephrology.
  • Facilitated expert consensus on best practices for drug development in kidney disease.
  • Highlighted the need for improved drug development pipelines to address CKD.

Conclusions:

  • Developing new drugs is essential for better treatment and patient care in CKD.
  • Optimizing translational research is key to accelerating the delivery of novel therapies.
  • International collaboration and strategic guidance are crucial for advancing kidney disease drug development.