Trends in Adipose-Derived Stem Cell-Conditioned Medium: A Bibliometric and Visualized Review

Area of Science:

• Biomedical Engineering
• Regenerative Medicine
• Stem Cell Biology

Background:

• Adipose-derived stem cell-conditioned medium (ADSC-CM) is a promising cell-free therapy.
• The rapid growth in ADSC-CM research necessitates systematic and quantitative reviews.
• Existing reviews may not capture the full scope or quantitative trends in ADSC-CM literature.

Purpose of the Study:

• To systematically analyze and visualize the characteristics of ADSC-CM research using bibliometric methods.
• To identify publication trends, collaborations, and emerging research hotspots in the ADSC-CM field.
• To provide a comprehensive overview of ADSC-CM development, challenges, and future directions.

Main Methods:

• Bibliometric analysis combined with conventional review methods.
• Utilized CiteSpace software for quantitative analysis and visualization.
• Analyzed publication trends, country/region, author, journal, and institution networks.
• Examined keyword co-occurrence, reference cocitation, and identified research clusters and emerging topics.

Main Results:

• ADSC-CM research is experiencing a significant growth phase, indicated by increasing publications and citations.
• Extensive international scientific collaborations and dense cocitation networks were observed.
• Identified key research clusters and emerging hot topics within the ADSC-CM field.
• The study provides a quantitative overview of the field's development and challenges.

Conclusions:

• ADSC-CM is a rapidly advancing field with robust scientific activity and collaboration.
• This bibliometric review offers a panoramic view of ADSC-CM research, aiding future study direction.
• The findings highlight the importance of quantitative analysis in understanding complex research landscapes.