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Experimental drugs in randomized controlled trials for long-COVID: what's in the pipeline? A systematic and critical

Shin Jie Yong1, Alice Halim2, Michael Halim3

  • 1Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Subang Jaya, Malaysia.

Expert Opinion on Investigational Drugs
|August 3, 2023
PubMed

Insights

Treatments for long-COVID remain elusive, with most investigational drugs showing limited potential. Rintatolimod, LTY-100, Treamid, and metformin show promise for specific long-COVID symptoms and prevention.

Area of Science:

  • Medical research
  • Infectious diseases
  • Pharmacology

Background:

  • Long-COVID, a post-COVID-19 syndrome, lacks standardized treatments despite its emergence over three years ago.
  • Limited funding for post-acute infection syndromes (PAIS) has historically hindered long-COVID research.
  • Recent years have seen increased investment, funding multiple randomized controlled trials (RCTs) to find effective treatments.

Approach:

  • This systematic review evaluated the potential of current drug treatments for long-COVID.
  • The review examined both completed and ongoing randomized controlled trials (RCTs).
  • Twenty-two unique drugs were investigated across four completed and 22 ongoing RCTs.

Key Points:

  • Most investigated drugs demonstrated low potential for treating long-COVID based on pre-specified criteria.
  • Long-COVID is a complex condition with proposed subtypes, suggesting a need for tailored treatments.
  • Rintatolimod shows potential for the ME/CFS subtype, LTY-100 and Treamid for pulmonary fibrosis, and metformin for general prevention.

Conclusions:

  • Current drug development for long-COVID faces significant challenges.
  • Tailored therapeutic strategies are likely necessary due to the multifaceted nature of long-COVID.
  • Further research and targeted drug development are crucial for effective long-COVID management.
Abstract

Keywords:
Long-COVIDdrugpost-COVID-19 syndromerandomized clinical trialtreatment

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