Related Experiment Video
Updated: Jul 20, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
Published on: May 6, 2019
CD4+ TIL to the Rescue of Anti-PD-1 Failure by Targeting MHC-II
Allison Betof Warner1,2, Jason J Luke3
1Stanford Cancer Institute, Palo Alto, California.
Abstract:
In this CCR Translations, we discuss the potential for tumor-infiltrating lymphocyte therapy to overcome immune checkpoint inhibitor resistance through CD4+-mediated and MHC-II-dependent killing. Validating these results from human tumors has potential to improve the clinical application of adoptive cellular transfer in advanced cancers. See related article by Draghi et al., p. 3937.
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