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Related Experiment Videos

Herpes simplex virus encephalitis. A case with dysplastic plasma cell infiltration.

G R Kelley, T Ashizawa, F Gyorkey

    Archives of Pathology & Laboratory Medicine
    |January 1, 1986
    PubMed
    Summary

    Herpes simplex virus (HSV) encephalitis can present with unusual plasma cell infiltrates mimicking neoplasm. Electron microscopy is crucial for diagnosing this subacute HSV encephalitis variant.

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    Area of Science:

    • Neurology
    • Virology
    • Pathology

    Background:

    • Herpes simplex virus (HSV) encephalitis is a severe neurological condition.
    • Diagnosis often relies on clinical presentation, CSF analysis, and neuroimaging.
    • Histopathological findings can vary, especially in later stages of the illness.

    Observation:

    • A case of HSV encephalitis was diagnosed late (31st day) via brain biopsy.
    • The biopsy revealed dense plasma cell infiltrates with dysplastic features, resembling plasma cell neoplasm.
    • Intranuclear virus particles were identified, confirming HSV infection.

    Findings:

    • Subacute HSV encephalitis can exhibit extensive plasma cell infiltrates.
    • These infiltrates may mimic plasma cell neoplasms histologically.

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  • Seroconversion detected by HSV-specific enzyme-linked immunosorbent assays (ELISA) correlated with the observed histopathology.

    • Implications:

    • This case highlights an unrecognized histopathological variant of HSV encephalitis.
    • Electron microscopy is essential for definitive diagnosis in such cases.
    • Understanding this variant aids in accurate diagnosis and patient management of HSV encephalitis.