Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

4.7K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
4.7K
Fractures: Bone Repair01:27

Fractures: Bone Repair

3.3K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.3K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

2.1K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.1K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

6.4K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementation of the HIP ATTACK Protocol Significantly Decreased Time to Surgery and Physical Therapy Evaluation for Hip Fracture Patients.

Journal of orthopaedic trauma·2026
Same author

Factors affecting time to surgery and mobilization following hip fracture.

Injury·2025
Same author

Risk factors for readmission and mortality after irrigation & debridement for septic arthritis in persons who inject drugs.

Journal of orthopaedics·2025
Same author

The fragility of statistical findings in the intertrochanteric fracture fixation literature: a systematic review of randomized controlled trials.

Archives of orthopaedic and trauma surgery·2025
Same author

Injection drug use is associated with repeat irrigation and debridement in native joint septic arthritis.

Journal of orthopaedics·2024
Same author

Rising rates of traumatic fractures among mountain bikers: A national review of emergency department visits.

Injury·2024

Related Experiment Video

Updated: Jul 20, 2025

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
07:01

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

10.2K

Heterotopic Ossification Remodeling After Acetabular Surgery: A Natural History Case Report.

Suzanne E Kent1, Scott P Ryan

  • 1Department of Orthopaedic Surgery, Tufts Medical Center, Boston, Massachusetts.

JBJS Case Connector
|August 3, 2023
PubMed
Summary

This case study highlights a rare instance of spontaneous remodeling of symptomatic heterotopic ossification (HO) following acetabular fracture surgery. The patient avoided surgical intervention due to natural symptom resolution and HO regression.

More Related Videos

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
09:51

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

2.7K
The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report
07:45

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

Published on: August 4, 2022

3.4K

Related Experiment Videos

Last Updated: Jul 20, 2025

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
07:01

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

10.2K
The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
09:51

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

2.7K
The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report
07:45

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

Published on: August 4, 2022

3.4K

Area of Science:

  • Orthopedic surgery
  • Trauma management
  • Regenerative medicine

Background:

  • Acetabular fractures are complex injuries requiring surgical intervention.
  • Heterotopic ossification (HO) is a known complication following acetabular trauma and surgery.
  • Surgical resection is the standard treatment for symptomatic HO.

Observation:

  • A patient with an acetabular fracture underwent operative fixation.
  • Postoperatively, the patient developed symptomatic heterotopic ossification (HO).
  • HO resection was planned but delayed due to external circumstances.

Findings:

  • The patient experienced spontaneous remodeling and regression of symptomatic HO.
  • Symptoms resolved without surgical intervention.
  • This represents a unique case of non-operative resolution of symptomatic HO.

Implications:

  • This case suggests that spontaneous regression of HO may occur, challenging the necessity of immediate surgical intervention in all cases.
  • Further research into the mechanisms of HO remodeling could inform future treatment strategies.
  • This finding may lead to a more conservative approach in managing symptomatic HO post-acetabular fracture.