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Peptide YY abnormalities in gastrointestinal diseases.
Gastroenterology
|February 1, 1986
Summary
Plasma concentrations of peptide YY (PYY) were significantly elevated in patients with steatorrhea due to small intestinal atrophy or pancreatitis. These findings offer insights into PYY
Area of Science:
- Gastroenterology
- Endocrinology
- Peptide Research
Background:
- Peptide YY (PYY) is a newly isolated peptide hormone.
- PYY is produced by endocrine cells in the ileum and colon.
- Its role in digestive disorders requires further elucidation.
Purpose of the Study:
- To measure plasma PYY concentrations in patients with various digestive disorders.
- To investigate the relationship between PYY levels and conditions like steatorrhea.
- To explore the physiological role of PYY in intestinal adaptation.
Main Methods:
- Standardized breakfast test administered to patient groups and healthy controls.
- Measurement of plasma PYY concentrations using established assays.
- Comparison of basal and postprandial PYY levels across different patient cohorts.
Main Results:
- Grossly elevated basal PYY levels (79 ± 18 pM) in patients with steatorrhea from tropical sprue, nearly 10-fold higher than controls (8.5 ± 0.8 pM).
- Substantially increased basal PYY (47.5 ± 6.3 pM) and exaggerated postprandial response in chronic destructive pancreatitis.
- Moderately elevated PYY in inflammatory bowel disease and recovering infective diarrhea; normal responses in diverticular disease, duodenal ulcer, and functional bowel disease.
Conclusions:
- Plasma PYY levels are significantly altered in specific digestive disorders, particularly those associated with steatorrhea.
- Elevated PYY may indicate impaired intestinal function or adaptation.
- Further research into PYY secretion patterns can illuminate its physiological role and implications for digestive health.
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