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Updated: Jul 20, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
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Published on: March 30, 2019

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Molecular profile of non-coding RNA-mediated glycolysis control in human cancers

Sepideh Mirzaei1, Bijan Ranjbar2, Saeed Hesami Tackallou3

  • 1Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran.

Pathology, Research and Practice
|August 3, 2023
PubMed

Insights

Non-coding RNAs (ncRNAs) regulate cancer cell glycolysis, impacting tumor growth and treatment response. Targeting these ncRNAs offers potential as cancer biomarkers and therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Glycolysis is crucial for cancer cell energy production and tumor growth.
  • Suppression of glycolysis can inhibit tumor progression.
  • Non-coding RNAs (ncRNAs) are key regulators of glycolysis in cancer.

Purpose of the Study:

  • To elucidate the role of ncRNAs in regulating cancer cell glycolysis.
  • To explore the impact of ncRNA-mediated glycolysis regulation on tumor proliferation, metastasis, and therapy response.
  • To identify ncRNAs as potential biomarkers for cancer diagnosis and prognosis.

Main Methods:

  • Review of literature on ncRNA regulation of glycolysis in cancer.
  • Analysis of mechanisms by which microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) target glycolysis.
  • Investigation of the role of ncRNAs in influencing tumor cell proliferation, metastasis, and response to cancer therapies.

Main Results:

  • ncRNAs, including miRNAs, lncRNAs, and circRNAs, significantly regulate cancer glycolysis.
  • miRNAs can inactivate glycolytic enzymes and suppress signaling pathways.
  • lncRNAs and circRNAs can sponge miRNAs, thereby controlling glycolysis and affecting tumor progression and therapy response.
  • ncRNA-mediated glycolysis regulation influences cancer metastasis.
  • Exosomal ncRNAs show promise as minimally-invasive biomarkers.

Conclusions:

  • ncRNAs are critical regulators of cancer glycolysis, influencing tumor behavior and treatment outcomes.
  • Targeting ncRNA-mediated glycolysis pathways presents a potential therapeutic strategy.
  • ncRNAs, particularly exosomal ncRNAs, are valuable biomarkers for cancer detection and monitoring.
Keywords:
Cancer therapyEpigenetic factorsNon-coding RNAsWarburg effect

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