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Updated: Jul 20, 2025

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

Exploring Colitis through Dynamic T Cell Adoptive Transfer Models.

Wenjing Yang^1,2, Yingzi Cong^1,2

¹Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

Inflammatory Bowel Diseases

|August 3, 2023

Summary

This summary is machine-generated.

Adoptive transfer models using CD4+ T cells are crucial for studying inflammatory bowel disease (IBD) pathogenesis. These models help researchers understand intestinal inflammation and develop new IBD therapies.

Keywords:

CBir1 CD45RBhi Th1 Th17 Treg

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Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

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Last Updated: Jul 20, 2025

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

Area of Science:

Immunology
Gastroenterology
Animal Models

Background:

Inflammatory bowel disease (IBD) pathogenesis is complex, involving aberrant immune responses.
CD4+ T cells are critical players in the development and progression of IBD.
Animal models are essential for dissecting the mechanisms underlying IBD.

Purpose of the Study:

To review the history, principles, and characteristics of T cell adoptive transfer models of colitis.
To discuss the strengths, limitations, and applications of these models in IBD research.
To highlight their value in investigating intestinal inflammation immunopathogenesis.

Main Methods:

Review of existing literature on T cell adoptive transfer colitis models.
Description of the CD4+ CD45RBhi T cell transfer model and its variations.
Analysis of model features, applications, and limitations.

Main Results:

T cell adoptive transfer models provide valuable insights into IBD pathogenesis.
The CD4+ CD45RBhi T cell transfer model is widely used but has variations.
Different models offer distinct features for studying intestinal inflammation.

Conclusions:

Adoptive transfer colitis models are indispensable tools for IBD research.
Understanding these models aids in elucidating IBD immunopathogenesis.
These models contribute to the development of novel therapeutic strategies for IBD.