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Related Experiment Videos

Macular development in the premature infant.

S J Isenberg

    American Journal of Ophthalmology
    |January 15, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Macular development in premature infants was classified, aiding gestational age estimation. Retinopathy of prematurity was linked to a two-week delay in macular development, suggesting a direct insult.

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    Area of Science:

    • Ophthalmology
    • Neonatology
    • Developmental Biology

    Background:

    • The macula's development is crucial for visual acuity.
    • Assessing gestational age in premature neonates is clinically important.
    • Retinopathy of prematurity (ROP) is a significant concern in preterm infants.

    Purpose of the Study:

    • To establish a classification system for the developing ophthalmoscopic appearance of the macula in premature neonates.
    • To correlate macular development with gestational age.
    • To investigate the impact of retinopathy of prematurity on macular development.

    Main Methods:

    • Retinal examinations were performed on 129 premature neonates.
    • A sequential classification of macular development was established from 34 to 42 weeks of gestational age.

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  • Macular development in infants with and without retinopathy of prematurity was compared.

    • Main Results:

    • A normal sequence of macular development was observed, enabling gestational age estimation.
    • Infants with or developing retinopathy of prematurity showed a statistically significant two-week delay in later-stage macular development.
    • This delay suggests a potential direct macular insult in retinopathy of prematurity.

    Conclusions:

    • The ophthalmoscopic appearance of the developing macula provides a reliable method for estimating gestational age in premature neonates.
    • Retinopathy of prematurity is associated with delayed macular development.
    • This study provides evidence for a direct macular insult in retinopathy of prematurity.