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Updated: Jul 20, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists

Wei Xie1, Lodoe Lama2, Xuejing Yang3

  • 1Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Cell Chemical Biology
|August 3, 2023
PubMed

Keywords:
2′,3′-cGAMPanalogs targeting STINGarabinose and xylose analogscancer therapeuticsresistance to ENPP1stability in human serumvaccine adjuvants

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