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An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging
Published on: September 24, 2017
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A phased array ultrasound system with a robotic arm for neuromodulation
Jongbum Seo1, Hyunsoo Shin2, Sungtaek Cho2
1Department of Biomedical Engineering, Yonsei University, Wonju, Gangwon-do, Korea.
Medical Engineering & Physics
|August 3, 2023
Summary
A novel phased array system enables precise, non-invasive ultrasonic neuromodulation (UNMOD) by electronically controlling focus. This technology demonstrates potential for highly selective brain stimulation and reproducible results in animal models.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Medical Devices
Background:
- Non-invasive brain stimulation using ultrasonic neuromodulation (UNMOD) faces limitations in region-specificity due to mechanical positioning errors.
- Single-element transducers with mechanical systems restrict the precision of UNMOD.
Purpose of the Study:
- To investigate the potential of a phased array system for highly selective neuromodulation with electronic control.
- To evaluate the region-specificity and reproducibility of UNMOD using a phased array system in a non-human primate model.
Main Methods:
- A specialized phased array ultrasonic system integrated with a robotic arm was employed in a rhesus monkey model.
- Stimulation targeted primary motor cortex areas controlling tail, hand, and mouth with a 200 μm step size.
- Specific ultrasonic parameters (840 mW/cm², 100 Hz PRF, 5% duty cycle, 600 kHz) were utilized, and induced movements were recorded.
Main Results:
- Electronic control of the phased array system successfully induced distinct movements in separate digits, mouth, and tongue.
- Reproducible movements were achieved by repositioning the electronic focus to the same primary motor cortex areas.
- The study partially validated the reproducibility of UNMOD in a rhesus monkey model.
Conclusions:
- Phased array systems offer a promising approach for non-invasive and region-selective neuromodulation.
- Electronic control enhances the precision and reproducibility of ultrasonic neuromodulation.
- This technology holds potential for advanced brain stimulation therapies.
