Related Experiment Video

Updated: Jul 20, 2025

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
09:37

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

15.1K

Evolving Understanding of Noncirrhotic Portal Hypertension

Raymond A Isidro1, Lei Zhao2

  • 1Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Surgical Pathology Clinics
|August 3, 2023
PubMed

Insights

Noncirrhotic portal hypertension, including porto-sinusoidal vascular disease (PSVD), has various causes. Understanding its pathological features is crucial for diagnosis, especially when the etiology is unknown.

Area of Science:

  • Hepatology
  • Vascular Medicine
  • Pathology

Background:

  • Cirrhosis is a common cause of portal hypertension.
  • Noncirrhotic portal hypertension arises from circulatory issues in prehepatic, intrahepatic, or posthepatic circulation.
  • Intrahepatic causes are further classified as presinusoidal, sinusoidal, or postsinusoidal.

Purpose of the Study:

  • To discuss the diagnostic pathological features of noncirrhotic portal hypertension.
  • To emphasize the characteristics of porto-sinusoidal vascular disease (PSVD).
  • To address the poorly understood etiology of idiopathic noncirrhotic portal hypertension, now classified as PSVD.

Main Methods:

  • Review of diagnostic pathological features.
  • Focus on histological findings in noncirrhotic portal hypertension.
  • Analysis of cases with unknown etiology (idiopathic PSVD).

Main Results:

  • Noncirrhotic portal hypertension encompasses diverse etiologies.
  • Porto-sinusoidal vascular disease (PSVD) is a key diagnostic consideration.
  • Pathological examination is essential for differentiating causes.

Conclusions:

  • Accurate pathological assessment is vital for diagnosing noncirrhotic portal hypertension.
  • Further research is needed to elucidate the causes of idiopathic PSVD.
  • Understanding PSVD's features aids in managing portal hypertension without cirrhosis.

Keywords:
Idiopathic noncirrhotic portal hypertensionPortal hypertensionPorto-sinusoidal vascular disease

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