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Basophil Activation Test for Allergy Diagnosis
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Recent updates in urticaria.

Ana M Giménez-Arnau1, Nerea Manzanares1, Indrashis Podder2

  • 1Department of Dermatology, Hospital del Mar-IMIM, Universitat Pompeu Fabra de Barcelona, Spain.

Medicina Clinica
|August 3, 2023
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Summary
This summary is machine-generated.

Urticaria, a common skin condition, involves hives and swelling. Emerging research reveals new disease types and targets, improving treatment for many patients.

Keywords:
AcuteAgudaChronicCrónicaDiagnosisDiagnósticoPathogenesisPatogeniaTratamientoTreatmentUrticaria

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Area of Science:

  • Dermatology
  • Immunology
  • Allergy

Background:

  • Urticaria presents as itchy wheals, with or without angioedema, and can be acute or chronic.
  • Chronic urticaria, often spontaneous, is primarily mast-cell and histamine-driven.
  • Recent insights implicate other inflammatory cells and cytokines, revealing IgE-mediated (type I) and IgG-mediated (type IIb) autoimmune endotypes.

Purpose of the Study:

  • To review the current understanding of urticaria, including its pathophysiology and classification.
  • To discuss established and emerging treatment strategies for urticaria.
  • To highlight the impact of urticaria on quality-of-life and the role of patient-reported outcomes.

Main Methods:

  • Literature review of urticaria pathogenesis, classification, and treatment.
  • Analysis of current therapeutic guidelines and emerging treatment targets.
  • Examination of patient-reported outcome measures in urticaria management.

Main Results:

  • Urticaria pathophysiology involves mast cells and histamine, with emerging evidence for autoimmune mechanisms.
  • Current treatments (antihistamines, omalizumab, cyclosporine) benefit 60-80% of patients.
  • Newer therapeutic targets are under investigation for refractory cases.

Conclusions:

  • Understanding urticaria endotypes is crucial for personalized treatment.
  • Optimizing evidence-based care requires evaluating disease activity and patient quality-of-life.
  • Future research directions aim to improve treatment efficacy and patient outcomes.