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Antral G- and D-cell counts in chronic renal failure
Scandinavian Journal of Gastroenterology
|January 1, 1979
Summary
Patients with chronic renal failure (CRF) have increased gastrin-producing cells (G cells) and somatostatin-producing cells (D cells). Hyperparathyroidism in CRF correlates with higher gastrin levels, suggesting a role in elevated gastrin.
Area of Science:
- Gastroenterology
- Nephrology
- Endocrinology
Background:
- Chronic renal failure (CRF) is associated with various endocrine and gastrointestinal disturbances.
- Gastric acid secretion and the regulation of gastric cells (D and G cells) may be altered in CRF.
Purpose of the Study:
- To investigate the density of antral somatostatin- and gastrin-producing cells (D and G cells) in patients with CRF.
- To evaluate the relationship between cell density, gastric acid secretion, and serum levels of gastrin, phosphate, and parathormone (PTH) in CRF patients.
Main Methods:
- Comparative study of CRF patients and a control group.
- Histological examination of antral biopsies to determine D and G cell density.
- Measurement of gastric acid secretion and serum levels of gastrin, phosphate, and PTH.
Main Results:
- CRF patients exhibited a mild increase in both D and G cell density compared to controls.
- Serum phosphate and PTH levels were elevated in CRF patients, indicating hyperparathyroidism.
- A direct correlation was observed between G cell density and parathyroid function in CRF patients.
Conclusions:
- Hyperparathyroidism appears to contribute to the elevated serum gastrin levels observed in patients with chronic renal failure.
- The findings suggest a link between altered parathyroid function and gastric endocrine cell changes in CRF.