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Related Experiment Videos

A general DNA analysis program for the Hewlett-Packard Model 86/87 microcomputer.

E H Harley

    Nucleic Acids Research
    |January 10, 1986
    PubMed
    Summary

    This study introduces a DNA sequence analysis program for the HP 86/87 microcomputer. It offers comprehensive tools for molecular biology research, including sequence manipulation and homology analysis.

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    Area of Science:

    • Molecular Biology
    • Bioinformatics
    • Computational Biology

    Background:

    • DNA sequence analysis is crucial for molecular biology research.
    • Limited accessible software tools were available for microcomputers in labs.

    Purpose of the Study:

    • To develop a versatile DNA sequence analysis program for the Hewlett-Packard Model 86/87 microcomputer.
    • To provide laboratory investigators with a tool for manipulating DNA constructs and analyzing sequences.

    Main Methods:

    • The program performs various analytical procedures including sequence display, restriction site mapping, and editing.
    • It includes functions for base frequency analysis, searching for repeated sequences, and identifying open reading frames.
    • Advanced features allow for sequence merging, homology comparison, and translation into amino acid sequences with detailed analysis.

    Main Results:

    • The program facilitates comprehensive DNA sequence analysis on a microcomputer with 128K RAM.
    • It enables detailed analysis of restriction sites, open reading frames, and amino acid properties.
    • The software supports sequence manipulation for simulating recombination strategies and performing homology searches.

    Conclusions:

    • This HP BASIC program serves as a valuable tool for laboratory researchers working with DNA sequences and recombinant constructs.
    • It enhances the capabilities of microcomputers for routine molecular biology data analysis.
    • The program's features support experimental design and interpretation in molecular genetics.

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