Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A spontaneous factor V inhibitor with unexpected laboratory features.

J T Brandt, A Britton, E Kraut

    Archives of Pathology & Laboratory Medicine
    |March 1, 1986
    PubMed
    Summary

    A spontaneous factor V inhibitor was initially misdiagnosed as a lupus anticoagulant. Careful integration of clinical and lab data led to correct diagnosis and successful treatment with platelets and immunosuppression.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Steatotic liver disease is a marker of multimorbidity, not underlying cirrhosis, in older adults.

    Npj gut and liver·2025
    Same author

    Does physical activity moderate the association between alcohol drinking and all-cause, cancer and cardiovascular diseases mortality? A pooled analysis of eight British population cohorts.

    British journal of sports medicine·2016
    Same author

    Ten-year alcohol consumption typologies and trajectories of C-reactive protein, interleukin-6 and interleukin-1 receptor antagonist over the following 12 years: a prospective cohort study.

    Journal of internal medicine·2016
    Same author

    Heart rate variability and depressive symptoms: a cross-lagged analysis over a 10-year period in the Whitehall II study.

    Psychological medicine·2016
    Same author

    Polioencephalomalacia and Heart Failure Secondary to Presumptive Thiamine Deficiency, Hepatic Lipidosis, and Starvation in 2 Abandoned Siamese Cats.

    Veterinary pathology·2016
    Same author

    The influence of fledgling location on adult provisioning: a test of the blackmail hypothesis.

    Proceedings. Biological sciences·2013

    Area of Science:

    • Hematology
    • Clinical Pathology

    Background:

    • Spontaneous inhibitors against coagulation factors can present diagnostic challenges.
    • Circulating anticoagulants may mimic other coagulation disorders, complicating patient management.

    Observation:

    • Initial laboratory findings suggested a nonspecific (lupus-like) inhibitor in a patient with a spontaneous factor V inhibitor.
    • The clinical history was inconsistent with the initial laboratory interpretation.

    Findings:

    • Further diagnostic evaluation identified a specific inhibitor against factor V.
    • The patient received successful treatment utilizing platelet therapy and immunosuppression.

    Implications:

    • This case emphasizes the limitations of certain laboratory tests for evaluating circulating anticoagulants.
    • Accurate diagnosis and management of factor V inhibitors require a comprehensive approach integrating clinical and laboratory data.

    Related Experiment Videos