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Selective nanosensor based on folic acid imprinted nanostructures.

Kevser Kuşat1, Serdar Şanli2, Suna Timur3

  • 1Department of Chemistry, Faculty of Science, Dokuz Eylül University, İzmir, Turkey.

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|August 4, 2023
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Summary

A novel folic acid (FA) imprinted nanosensor on surface-printed carbon electrodes was developed for sensitive and selective FA determination in human blood serum. This cost-effective method offers rapid analysis for biological samples.

Keywords:
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Area of Science:

  • Electrochemistry
  • Nanotechnology
  • Biochemistry

Background:

  • Folic acid is crucial for metabolism, nucleotide synthesis, and methylation, with deficiencies leading to various disorders.
  • Accurate folic acid determination methods are essential for diagnosing and managing related health conditions.
  • Current methods for folic acid analysis require innovative, cost-effective, and sensitive approaches.

Purpose of the Study:

  • To develop a novel folic acid imprinted nanostructure-modified surface-printed carbon electrode (SPCE) for folic acid determination.
  • To create a highly selective and sensitive nanosensor for detecting folic acid in human blood serum.
  • To establish a rapid and cost-effective electrochemical method for folic acid analysis.

Main Methods:

  • Synthesis and characterization of folic acid imprinted nanostructures (FA-Imp-poly(MPTS-rGO-co-NAT)) using FTIR, SEM-EDS, and AFM.
  • Fabrication of a nanosensor by modifying SPCE with the synthesized nanostructures.
  • Electrochemical analysis using differential pulse voltammetry (DPV) and cyclic voltammetry (CV).

Main Results:

  • The developed FA-imprinted nanosensor exhibited a low detection limit (LOD) of 7.54 ng/mL and a quantification limit (LOQ) of 25.14 ng/mL.
  • High precision was demonstrated with relative standard deviation (RSD) values as low as 0.092% in DPV measurements.
  • The nanosensor showed selectivity and sensitivity for folic acid determination in synthetic serum samples.

Conclusions:

  • A novel, simple, selective, and rapid folic acid imprinted nanosensor has been successfully developed.
  • The developed electrochemical nanosensor is suitable for the quantitative determination of folic acid in biological samples like human blood serum.
  • This innovative approach offers a promising tool for clinical diagnostics and metabolic studies related to folic acid.