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Assessing causal relationships between gut microbiota and asthma: evidence from two sample Mendelian randomization
1Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in Immunology
|August 4, 2023
Summary
This study investigated the causal link between gut bacteria and asthma. Certain gut microbes are genetically linked to asthma risk and its subtypes, suggesting potential new diagnostic and prevention strategies.
Area of Science:
- Microbiome research
- Genetic epidemiology
- Respiratory medicine
Background:
- Gut microbiota dysbiosis is frequently observed in asthma patients.
- The causal relationship between gut microbiota and asthma remains unclear.
- This study investigates the genetic causality between gut microbiota and asthma, including its phenotypes.
Conclusions:
- Specific gut microbial genera are causally associated with asthma and its phenotypes.
- Findings enhance understanding of gut microbiota's role in asthma pathology.
- Highlights potential for novel asthma prevention and diagnostic strategies targeting the gut microbiome.
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