Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sulphated polysaccharides, corticosteroids and lymphocyte recirculation.

J G Hall

    Immunology
    |February 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Preservation of erniettomorph fossils in clay-rich siliciclastic deposits from the Ediacaran Wood Canyon Formation, Nevada.

    Interface focus·2020
    Same author

    The early history of Pallister-Hall syndrome-Buried treasure of a sort.

    Gene·2016
    Same author

    Biliglobulin: a new look at IgA.

    Immunology today·2014
    Same author

    [Not Available].

    Immunology today·2014
    Same author

    Is IgA production T-cell dependent?

    Immunology today·2014
    Same author

    Exome sequencing identifies mutations in KIF14 as a novel cause of an autosomal recessive lethal fetal ciliopathy phenotype.

    Clinical genetics·2013

    Sulphated polysaccharides like fucoidan significantly reduce lymphocyte recirculation. This effect appears secondary to increased corticosteroid hormone secretion, not a direct action on lymphocytes.

    Area of Science:

    • Immunology
    • Endocrinology

    Background:

    • Lymphocyte recirculation is crucial for immune surveillance.
    • Sulphated polysaccharides are known to modulate immune responses.

    Purpose of the Study:

    • To investigate the effect of sulphated polysaccharides on lymphocyte recirculation.
    • To determine the mechanism behind fucoidan's impact on lymphocyte traffic.

    Main Methods:

    • Collected lymph from sheep before and after intravenous injection of fucoidan.
    • Measured lymphocyte recirculation rates.
    • Administered dexamethasone and monitored cortisol levels.

    Main Results:

    • Intravenous fucoidan caused an >80% acute reduction in lymphocyte recirculation.

    Related Experiment Videos

  • Dexamethasone mimicked fucoidan's effect on lymphocyte recirculation.
  • Fucoidan injection led to a 10-fold increase in plasma cortisol.

    • Conclusions:

    • The impact of sulphated polysaccharides on lymphocyte recirculation is primarily mediated by increased corticosteroid secretion.
    • The effects are largely indirect and non-specific, linked to the endocrine stress response.