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Updated: Jul 20, 2025

Extraction of Extracellular Vesicles from Whole Tissue
Published on: February 7, 2019
Research progress in role of exosomes exosomes in mental disorders
Jialing Wu1, Shansi Li2, Yi Zhang3,4,5
1Medical Psychological Center, Second Xiangya Hospital, Central South University, Changsha 410011. 208211161@csu.edu.cn.
Abstract:
Exosomes are a class of extracellular vesicles with a structure of lipid bilayer-membrane. In the central nervous system (CNS), exosomes can be secreted from both neurons and glial cells. Exosomes released into the extracellular matrix can freely cross the blood-brain barrier and function as crucial carriers of cellular communication and substance exchange in the CNS. Exosomes play a key role in the pathological process of mental disorders such as schizophrenia, depression, and bipolar disorder, and they have the potential to be used as a targeted carrier of antipsychotic medications. Exosomes are likely to become a new tool in the future to aid in the early prevention, accurate diagnosis, and effective treatment for people with mental disorders.
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