Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

Oral Hypoglycemic Agents: Biguanides and Glitazones

234
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
234
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

358
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
358
Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

741
Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
741
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

211
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
211
Oral Hypoglycemic Agents: Sulfonylureas01:17

Oral Hypoglycemic Agents: Sulfonylureas

244
Sulfonylureas are oral hypoglycemic agents utilized in treating type 2 diabetes. They are characterized by their unique sulfonylurea chemical structure. The family of sulfonylureas is divided into generations. First-generation sulfonylureas, including tolbutamide (Orinase), chlorpropamide (Diabinese), and tolazamide (Tolinase), trigger insulin release from pancreatic β cells and enhance peripheral tissues' insulin sensitivity. The second-generation members, such as glipizide...
244
Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

186
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
186

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

A new device for simultaneous cooling of the drop and evaporated sample for the extraction of volatile components using cooled side arm tube headspace microextraction.

Journal of chromatographic science·2026
Same journal

Simultaneous quantitation of oleanolic and ursolic acids by RP-HPLC-DAD on active ingredient from Tabebuia hypoleuca leaves.

Journal of chromatographic science·2026
Same journal

Development and validation of gas chromatography-mass spectrometry method for identification and quantification of selected non-intentionally added substances IN pharmaceutical formulations.

Journal of chromatographic science·2026
Same journal

A simple method for the determination of Atrazine in lake water by gas chromatography with electron capture detector (GC-ECD) using dispersive liquid-liquid microextraction (DLLME).

Journal of chromatographic science·2026
Same journal

Investigation of surface properties of various parts of Angelica sylvestris by inverse gas chromatography.

Journal of chromatographic science·2026
Same journal

Development and validation of stability-indicating RP-HPLC method for simultaneous estimation of clomiphene citrate and co-enzyme Q10 in bulk and pharmaceutical dose.

Journal of chromatographic science·2026
See all related articles

Related Experiment Video

Updated: Jul 20, 2025

An In Ovo Model for Testing Insulin-mimetic Compounds
06:09

An In Ovo Model for Testing Insulin-mimetic Compounds

Published on: April 23, 2018

10.7K

Thiazolidinediones: Recent Development in Analytical Methodologies.

Tarang Patel1, Vatsal Patel2

  • 1Department of Pharmaceutical Quality Assurance, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Charusat Campus, Changa 388 421, Gujarat, India.

Journal of Chromatographic Science
|August 4, 2023
PubMed
Summary
This summary is machine-generated.

This review details analytical methods for thiazolidinedione determination in medications and biological fluids from 2001-2022. It highlights advances in chromatographic and spectrometric techniques for key drugs like pioglitazone.

More Related Videos

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

4.5K
Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

9.3K

Related Experiment Videos

Last Updated: Jul 20, 2025

An In Ovo Model for Testing Insulin-mimetic Compounds
06:09

An In Ovo Model for Testing Insulin-mimetic Compounds

Published on: April 23, 2018

10.7K
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

4.5K
Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

9.3K

Area of Science:

  • Analytical Chemistry
  • Pharmaceutical Chemistry

Background:

  • Thiazolidinediones are crucial pharmaceutical compounds.
  • Accurate determination in various matrices is essential for quality control and therapeutic monitoring.

Purpose of the Study:

  • To comprehensively review instrumental analytical methods for thiazolidinedione determination.
  • To cover literature published between 2001 and 2022.
  • To focus on advancements in analyzing specific thiazolidinediones: pioglitazone, pioglitazone HCl, rosiglitazone, rosiglitazone maleate, and lobeglitazone.

Main Methods:

  • Literature review of analytical and pharmaceutical chemistry journals.
  • Analysis of chromatographic techniques (e.g., HPLC, GC).
  • Evaluation of spectrometric analytical procedures (e.g., UV-Vis, Mass Spectrometry).

Main Results:

  • Compilation of diverse analytical approaches including complex methods, chromatography, and spectrometry.
  • Identification of critical parameters influencing thiazolidinedione analysis (mobile phase, flow rate, wavelength, etc.).
  • Review of recent analytical method developments for specific thiazolidinediones.

Conclusions:

  • Significant advancements in analytical methodologies for thiazolidinediones have been achieved.
  • The review provides a consolidated resource for analytical discoveries related to thiazolidinediones.
  • Future research can build upon these findings for improved drug analysis.