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Role of miR‑181a‑5p in cancer (Review)

Junxin Li1, Jing Shen2, Yueshui Zhao2

  • 1Department of Pharmacy, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

International Journal of Oncology
|August 4, 2023
PubMed

Insights

MicroRNAs (miRNAs), like miR-181a-5p, regulate genes and impact diseases. This review details miR-181a-5p

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are non-coding RNAs regulating gene expression.
  • Dysregulated miRNAs are implicated in various diseases, including cancer.
  • miR-181a-5p is a conserved miRNA involved in pathological processes.

Approach:

  • Comprehensive review of recent research on miR-181a-5p.
  • Focus on its role in cancer development and progression.
  • Analysis of its function in angiogenesis, inflammation, and obesity.

Key Points:

  • miR-181a-5p acts as an oncomiR or tumor suppressor in different cancers.
  • It influences multiple hallmarks of cancer through gene suppression.
  • Its precise role in cancer pathogenesis requires further elucidation.

Conclusions:

  • miR-181a-5p has a complex role in various cancer types.
  • It shows potential as a diagnostic and prognostic biomarker.
  • Understanding its function in chemoresistance is crucial for therapeutic strategies.
Keywords:
biomarkercancerschemoresistancemiR‑181a‑5p

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