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Dina Overgaard Eriksen1,2, Marianne Pape3, Lone Kjeld Petersen4,5

  • 1Kvindesygdomme og Fødsler, Regionshospitalet Gødstrup.

Ugeskrift for Laeger
|August 4, 2023
PubMed
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Immunocompromised women face higher risks of human papillomavirus (HPV) infection and related diseases. While HPV vaccination shows immunogenicity in these individuals, its effectiveness in preventing cervical dysplasia and cancer requires further investigation.

Area of Science:

  • Oncology
  • Immunology
  • Public Health

Background:

  • Immunocompromised women exhibit elevated susceptibility to human papillomavirus (HPV) detection and associated conditions, including genital warts, anogenital dysplasia, and cancer.
  • The review focuses on the immune response to HPV vaccination in immunocompromised women and its potential role in mitigating cervical dysplasia and cancer risks.

Approach:

  • Systematic review of current literature on HPV vaccine immunogenicity in immunocompromised populations.
  • Analysis of existing data to evaluate the potential efficacy of HPV vaccination in reducing HPV-related cervical diseases.

Key Points:

  • HPV vaccination elicits an immune response in immunocompromised women.
  • The efficacy of HPV vaccination in preventing cervical dysplasia and cancer in this demographic remains undetermined.

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  • Further research is essential to ascertain the protective benefits of HPV vaccination for immunocompromised women.

    • Conclusions:

    • HPV vaccination is immunogenic in immunocompromised women, but clinical effectiveness is not yet established.
    • The potential of HPV vaccination to reduce the incidence of cervical dysplasia and cancer in immunocompromised women warrants additional investigation.
    • More research is needed to confirm the protective role of HPV vaccination in this high-risk group.